| 1980 | Registration of Matrusri Education Society |
| 1981 | Inauguration of the college by Sri T. Anjiah, Chief Minister, AP at temporary premises at Ameerpet, with an intake of 180 in Civil, ECE and Mechanical disciplines |
| 1983 | Shifting of the college to Saidabad Campus |
| 1985 | Starting of BE (CSE) Course |
| 1986 | Inauguration of the Administrative block at Saidabad Campus by Sri P. V. Narasimha Rao, Minister of Human Resources, Govt. of India. |
| 1991 | Decemal Celebrations: Starting of awarding Gold Medals to Class Toppers by MECT |
| 1992 | Purchase of 10,000 sq.yds. land at Saidabad Campus, Starting of awarding Gold Medals to Best Teachers by MECT |
| 1993 | Permanent affiliation for Civil, Mech., ECE, and CSE by OU |
| 1994 | Start of MCA Course, 19 Acres land was purchased at Nadergul by MES |
| 1995 | Foundation Stone of Science Block laid at Nadergul Campus by Sri M. Gopal Rao |
| 1997 | Shifting of 1 year to Nadergul Campus, Starting of BE (EEE) & MBA Courses |
| 2000 | Shifting of all Engineering disciplines to Nadergul Campus, Start of BE (IT) Course |
| 2000 | Formation of Matrusri Institute of PG Studies with MCA and MBA at the Saidabad Campus |
| 2001 | Starting of BE (Production) Course |
| 2002 | Inauguration of Canteen and Physical Education Dept. block |
| 2003 | First AICTE (MODROBS) Grant received |
| 2004 | Inauguration of CS & IT block by Sri V. Rama Rao, Governor of Sikkim |
| 2004 | Construction of Bank building for the College |
| 2005 | Start of first PG course M.E (CAD / CAM) in Mech. Engg. Dept. |
| 2006 | Construction of 5,000 sqm area on 11 floor of Civil, Mechanical and CS & IT blocks |
| 2008 | Start of MCA Course, New library building with 20,000 sqft. |
